Hep C Sufferers

Overview of Sofosbuvir (Sovaldi).

Sofosbuvir is the Generic name of the drug Sovaldi which is used for treating hepatitis C. It is not used as a standalone medication and is generally combined with other antiviral medications such as ribavirin only, both ribavirin and interferon or ledipasvir for treating hepatitis genotype 1. The combined medication is an effective agent for the treatment of hepatitis C by decreasing the overall level of infection within the body, which offers the liver an opportunity for to repair and recover.

In addition to decreasing the levels of infection within the body, the drug also helps boost the immune system to fight against infection. sofosbuvir is a relatively new medication, only being marketed since 2013, and is considered as significant advancement in the treatment options for hepatitis C. However, it is important to note, it’s unknown if sofosbuvir can help prevent passing hepatitis C from one person to another through unprotected sex or by sharing needles but the issue continues to be studied. Additionally, the drug should not be used alone and is most effective when used as a combined medication.

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Using sofosbuvir.

Sofosbuvir is designed to be taken orally based on instructions given by your doctor or medical professional. It can be taken with or without food and the dosage can vary depending on your individual health situation and medical diagnosis. Typically dosage is recommended as once per day but this also varies according to how your body responds to treatment.

The effectiveness of sofosbuvir is best when patients are able to maintain consistent levels of the medication present in their body at all times. Therefore, consuming the medication based on even and consistent intervals is typically the recommended procedure. It’s also important to remember that you should always complete the full course of treatment and consume all of the medication prescribed based on the prescribed schedule even if you begin to feel like you have recovered and symptoms are no longer present. If you quit taking the prescribed medication to early then there is always a chance an infection can reoccur. 

Interactions of Sofosbuvir (sovaldi)?

Drug interaction classifications are difficult to determine as there are many variables involved and an individual’s health and medical status always play a large role. However, there are some general guidelines that can be used for informational purposes only. For specific information on drug interaction always consult with your physician.

Medication Interaction Classifications:


You should almost always avoid combinations in this category as the risk of interaction with adverse health effects is very high.


You should normally avoid combinations in this category and only use if specifically directed by your physician under very particular circumstances.


These combinations should generally be avoided and an alternative medication is usually a better option. If using medication in this category is recommended then constant monitoring of the situation is usually recommended.

Generally speaking, sofosbuvir has five major, nineteen moderate and one minor medication interactions although this can greatly depend on individual circumstances. Major interactions include Amiodarone, Isoniazid-Pyrazinamide-Rifampin, Isoniazid-Rifampin, Rifampin and St. John's Wort and the minor interaction includes Cyclosporine. You can view a list of known moderate interactions below as follows:

Moderate Interactions:

  • Aminophylline-ephedrine-guaifenesin-phenobarbital
  • Aminophylline-ephedrine-phenobarbital-potassium iodide
  • Atropine-hyoscyamine-phenobarbital-scopolamine
  • Atropine-phenobarbital
  • Belladonna-ergotamine-phenobarbital
  • Carbamazepine
  • Dyphylline-ephedrine-guaifenesin-phenobarbital
  • Ephedrine-phenobarbital-potassium iodide-theophylline
  • Ephedrine-phenobarbital-theophylline
  • Fosphenytoin
  • Hyoscyamine-phenobarbital
  • Modafinil
  • Oxcarbazepine
  • Phenobarbital phenytoin primidone
  • Rifabutin rifapentine
  • Tipranavir

The information above about drug interactions with sofosbuvir should not be considered complete or official and is for informational purposes only. Always consult your physician for information regarding your individual circumstances.


Warnings, Precautions and Side Effects.

While sofosbuvir has been proven as a very effective medication for the treatment of hepatitis C, just like any other type of medication, it does have specific warnings and precautions that potential users should take note of.

sofosbuvir Precautions

  • sofosbuvir has been researched and tested in situations for use with patients that have liver cancer and are due to have a liver transplant performed as well as patients that suffer from different levels of liver failure. However, the drug has not undergone extensive research when it comes to use with patients that suffer from cirrhosis and medical professional should always be consulted before use.
  • Proper precaution and consultation with a licensed physician should always be followed to ensure any drugs you are currently taking are safe for use with sofosbuvir.
  • sofosbuvir is considered relatively safe for use during pregnancy and is considered a category B pregnancy medication. However, it’s important to for potential users to understand that sofosbuvir is almost always used in combination with another or other medications, such as ribavirin. Ribavirin is classified as a category X pregnancy medication and should never be used with or without sofosbuvir if you are pregnant. The health consequences can be very dangerous and there are many potential side effects.
  • If you are breastfeeding, it’s important to consult your physician before using sofosbuvir. It is not known if sofosbuvir transfers via breast milk and what potential effects it could have on a child.

Side Effects

Almost every type of prescribed medication has the potential of producing side effects that range between major and mild. The most common known side effects of taking sofosbuvir depend on your individual health as well as the specific course of treatment that is prescribed. Side effects can vary widely when using sofosbuvir because it is used in combination with other medications so it’s important to always check with your doctor for information regarding potential side effects based on your individual situation.

Some of the most common side effects of using sofosbuvir include chills, fever, back pain, ulcers and fatigue. These side effects are not always produced by using the medication but there is always a chance the drug could produce them. Other more mild side effects include headaches, reduced appetite, diarrhea, nausea and itchy skin.

Most of the side effects involved with sofosbuvir are relatively mild and do not present severe health risks. However, there is always potential for serious health risks on an individual basis and it is never safe to begin using medication unless it is approved by a licensed physician beforehand.

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